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Lu Research Group Welcomes You

Bioinorganic Engineering

From Innovative Design & Synthesis toward Novel Biomedical Application

Our team welcomes you to join the interdisciplinary research covering chemistry, material science, biology, and biomedical engineering.​

RECRUIT: Welcome to join our lab

We are looking for international MS and PhD students who are enthusiastic, honest, and  passionate about research.

For scholarship details provided by the Taiwan government ; the international students please visit this website

https://tafs.mofa.gov.tw/Contents.aspx?loc=en

The other Scholarships provided by  National Tsing Hua University ; please visit the following link.

http://oga.nthu.edu.tw/web.page/detail/sn/76/lang/en

 
 

Research Interests

Bioinorganic Engineering

Utilization of metal ions as structural and functional motif assembles metalloenzymes and metalloproteins for a variety of essential processes in biological system. Through artificial evolution, bioinorganic engineering defines the translational incorporation of the inherited nature of synthetic metallocofactors, including (catalytic) reactivity, redox activity, photophysical properties (X-ray, UV-vis, NIR, etc.), and magnetic properties, into organic and inorganic polymers for functional applications. In this bioinorganic engineering lab, we aim to control the generation, capture, stabilization, delivery, transformation, and detection of bioactive gaseous molecules, such as nitric oxide, dihydrogen, and carbon dioxide. Through the  iterative study on structure  and reactivity of dinitrosyl  iron unit [Fe(NO)2], metal-pyrazolate framework, and MOF-derived metal nanoparticle@carbon materials, controlled manipulation of bioactive gaseous molecules will be translated to cancer treatment and regenerative medicine.

 

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Spatial, Dosage, and Temporal Control on the Delivery of Nitric Oxide  for Regenerative and Cancer Therapy

Nitric oxide features ubiquitous physiology in respiration, (cardio)vascular, myocardial, immune, and neuronal system. Difficulty in the controlled delivery of nitric oxide, however, retards the translational application in pharmacology and biomedical engineering. In our lab, we utilized the dinitrosyl iron complexes (DNICs) as a novel prodrug for the delivery of nitric oxide and for the NO-related biomedical application. Relying on our development of the synthetic strategy for DNICs, a chemical library of DNICs was established.In terms of controlled release of nitric oxide, we discovered the controlled release of nitric oxide from DNICs triggered by pH, O2, temperature, photolysis, and magnetic field. On the other hand, we successfully applied DNICs for the NO-related anti-aging effect in C. elegans; vasodilation, myocardial relaxation, and myocardial inotropy effect in zebrafish; and reduction of blood pressure, enhancement of angiogenesis, osteogenesis, neurogenesis, tumor vessel normalization, anti-cancer effect, and anti-inflammatory effect in mouse. Regarding the development of DNICs for the delivery of nitric oxide in vivo, we welcome you to continue the investigation of DNICs for NO-related biomedical application through the conjugation with alternative biomedical materials and devices.

H2_1

H2_1

Controlled Generation and Detection of Dihydrogen

Besides its utilization as a renewable and clean energy source, dihydrogen features unexplored potential in inflammatory disease relying on its antioxidant reactivity, in particular, toward hydroxyl radical. However, limited solubility of H2 in aqueous solution and lack of a delivery system hamper the therapeutic efficiency and retard its biomedical application. In our lab, we discovered DNICs as a precursor for preparation of the Fe@FeOx electrode featuring electrocatalytic HER reactivity. To control the location of delivered dihydrogen, development of metal-organic frameworks (MOF) derived metal@porous carbon as implantable materials for catalytic generation of dihydrogen is undergoing. Moreover, MOF-derived metal nanoparticles shielded by porous carbon provide a mechanism for the steady, instead of burst, generation of dihydrogen.

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CO2_1

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Direct Air Capture and Controlled Transformation of Carbon Dioxide

魯才德 Tsai-Te (Shawn) Lu

Institute of Biomedical Engineering, National Tsing Hua University

​國立清華大學 生物醫學工程所

101, Section 2, Kuang-Fu Rd., Hsinchu, Taiwan 30013

TTLu@mx.nthu.edu.tw

EDUCATION

  • B.S. in Chemistry, National Tsing Hua University, 2005.

  • Ph. D. in Chemistry (Prof. Wen-Feng Liaw, specialized in bioinorganic chemistry), National Tsing Hua University, 2009.

RESEARCH EXPERIENCE

  • Associate Professor

          Institute of Biomedical Engineering, National Tsing Hua University            08/2020- present

  • Assistant Professor

          Institute of Biomedical Engineering, National Tsing Hua University            08/2017- 07/2020

  • Assistant Professor

          Chung Yuan Christian University           08/2013-07/2017

  • Post-doc Research Fellow, Massachusetts Institute of Technology

​          Advisor: Prof. Stephen J. Lippard            3/2011 – 7/2013​

  • Post-doc Research AssociateNational Tsing Hua University

          Advisor: Prof. Wen-Feng Liaw                  12/2009-02/2011

  • Graduate Research AssistantNational Tsing Hua University

          Advisor: Prof. Wen-Feng Liaw                   08/2005-12/2009

AWARDS

  • Young Investigator Award from College of Engineering, NTHU, Taiwan (2020)

  • Young Investigator Award from Chao-Jen Lee (李昭仁) Biomaterial Research Foundation (2019)

  • Graeme-Hanson-AsBIC Early Career Researcher Award (2018)

  • Rising Star Award, 43rd International Conference on Coordination Chemistry (2018)

  • Excellent Teaching Award, Dept. of Chemistry, Chung Yuan Christian University (2016)

  • Excellent Mentor Award, Dept. of Chemistry, Chung Yuan Christian University (2016)

  • Recruitment of Special Outstanding Talents, MOST (2013)

  • Postdoctoral Research Abroad Program Fellowship, National Science Council (2011)

  • The Phi Tau Phi Scholastic Honor,
    The Phi Tau Phi Scholastic Honor Society of the Republic of China (2010)

  • NTHU President’s Scholarship, National Tsing Hua University (2006)

PATENTS

  • Tsai-Te Lu, Hsiao-Wen Huang, Chia-Her Lin, Yu-Ting Tseng, Wen-Feng Liaw, Hsi-Ya Huang, Show-Jen Chiou “DINITROSYL IRON COMPLEX, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, COMPOSITE MATERIAL COMPRISING THE SAME, AND USES THEREOF” U.S. Patent Application No. 15/413,428, January 24, 2017.

 

Lab Members

魯才德 Tsai-Te Lu(Shawn)
Principal Investigator
Manmath Narwane馬勝杰
Post-doc
曾宇霆
PhD Student
黃怡達
Research Assistant
鍾介偉
Graduate Student
方敏瑄
Graduate Student
吳承儒
Graduate Student
張昱翔
Graduate Student
洪詠惠
Graduate Student
廖呈哲
Graduate Student
陳奕宏
Graduate Student
廖博文
Graduate Student
游子頡
Graduate Student
林咨喆
Undergraduate Student
林青慧
Undergraduate Student
張承翰
Undergraduate Student
Show More
黃振庭
Alumni
陳秉鋐
Alumni
王美仁
Alumni
賴沅鋐
Alumni
陳毅
Alumni
林稼芳
Alumni
Alumni
Show More
 
 
 

Publication List

  • Tseng, Y.-T.; Ching, W.-M.; Liaw, W.-F.*; Lu, T.-T.* “Dinitrosyl Iron Complex [K-18-crown-6-ether][(NO)2Fe(MePyrCO2)]: Intermediate for Capture and Reduction of Carbon Dioxide.” Angew. Chem. 2020, 59, 11819-11823 (SCI IF 12.257; ranking 17/172 = 9.9%, Chemistry, Multidisciplinary).

  • Lu, S.; Chiou, T.-W.*; Li, W.-L.; Wang, C.-C.; Wang, Y.-M.; Lee, W.-Z.; Lu, T.-T.*; Liaw, W.-F.* “Dinitrosyl Iron Complex [(PMDTA)Fe(NO)2]: Intermediate for Nitric Oxide Monooxygenation Activity in Non-Heme Iron Complex” Inorg. Chem. 2020, 59, 8308-8319 (SCI IF 4.850; ranking 4/45 = 8.89%, CHEMISTRY, INORGANIC & NUCLEAR)

  • Santos, J. H.; Quimque, M. T. J.; Macabeo, A. P. G.; Corpuz, M. J.-A. T; Wang, Y.-M.; Lu, T.-T.; Lin, C.-H.; Villaflores, O. B.* “Enhanced Oral Bioavailability of the Pharmacologically Active Lignin Magnolol via Zr-Based Metal Organic Framework Impregnation.” Pharmaceutics 2020, 12, 437 (SCI IF 4.774; ranking 26/267 = 9.7%, PHARMACOLOGY & PHARMACY).

  • Hsueh, Y.-J.; Meir, Y.-J.; Yeh, L.-K.; Wang, T.-K.; Huang, C.-C.; Lu, T.-T.; Cheng, C.-M.; Wu, W.-C.; Chen, H.-C. “Topical Ascorbic Acid Ameliorates Oxidative Stress-Induced Corneal Endothelial Damage via Suppression of Apoptosis and Autophagic Flux Blockage.” Cells 2020, 9, 943 (SCI IF 5.656; ranking 40/193 = 20.7%, Cell Biology).

  • ​Hsueh, Y.-J.; Meir, Y.-J.; Lai, J.-Y.; Chen, H.-C.; Ma, H.-K.; Huang, C.-C.; Lu, T.-T.; Cheng, C.-M.; Wu, W.-C. “Lysophosphatidic acid improves corneal endothelial density in tissue culture by stimulating stromal secretion of interleukin-1β” J. Cell Mol. Med. 2020, ASAP (SCI IF 4.658; ranking 31/136 = 22.8%, medicine, research & experimental).

  • ​Sung, Y.-C.; Jin, P.-R.; Chu, L.-A.; Hsu, F.-F.; Wang, M.-R.; Chang, C.-C.; Chiou, S.-J.; Qiu, J. T.; Gao, D.-Y.; Lin, C.-C.; Chen, Y.-S.; Hsu, Y.-C.; Wang, J.; Wang, F.-N.; Yu, P.-L.; Chiang, A.-S.; Wu, A. Y.-T.; Ko, J. J.-S.; Lai, C. P.-K.; Lu, T.-T.*; Chen, Y. “Delivery of Nitric Oxide with a Nanocarrier Promotes Tumour Vessel Normalization and Potentiates Anti-Cancer Therapies” Nat. Nanotechnol.  (SCI IF 33.407).

  • Chen, Y.-J.; Wu, S.-C.; Wang, H.-C.; Wu, T.-H.; Yuan, S.-S. F.*; Lu, T.-T.*; Liaw, W.-F.*; Wang, Y.-M.* “Activation of Angiogenesis and Wound Healing in Diabetic Mice Using NO-Delivery Dinitrosyl Iron Complexes” Mol. Pharmaceutics 2019, 16, 4241-4251. (SCI IF 4.396).

  • Cho, S.-L.; Liao, C.-J.; Lu, T.-T.* “Synthetic methodology for preparation of dinitrosyl iron complexes” J. Biol. Inorg. Chem. 2019, 24, 495-515. (SCI IF 2.894).

  • Hsiao, H.-Y.; Chung, C.-W.; Santos, J. H.; Villaflores, O. B.; Lu, T.-T.;* “Fe in Biosynthesis, Translocation, and Signal Transduction of NO: Toward Bioinorganic Engineering of Dinitrosyl Iron Complexes into NO-delivery Scaffolds for Tissue Engineering” Dalton Trans. 2019, 48, 9431-9453. (Invited Review Article in themed issue: d Block Chemistry). (SCI IF 4.099) 6/45 = 13.33% (CHEMISTRY, INORGANIC & NUCLEAR)

  • Huang, H.-C.; Ching, W.-M.; Tseng, Y.-T.; Chen, C.-H.* Lu, T.-T.;* “Transformation of Hydride-Containing Dinitrosyl Iron Complex [(NO)2Fe(h2-BH4)]– into [(NO)2Fe(h3-HCS2)]– via Reaction with CS2” Dalton Trans. 2019, 48, 5897-5902. (SCI IF 4.099) 6/45 = 13.33% (CHEMISTRY, INORGANIC & NUCLEAR)

  • Lu, T.-T.;* Wang, Y.-M.;* Hung, C.-H.;* Chiou, S.-J.;* Liaw, W.-F.* “Bioinorganic Chemistry of the Natural [Fe(NO)2] Motif: Evolution of a Functional Model for NO-Related Biomedical Application and Revolutionary Development of a Translational Model” Inorg. Chem. 2018, 57, 12425-12443.

  • Huang, H.-W.; Lin, M.-H.; Lin, Y.-H.; Huang, Y.-R.; Chou, C.-H.; Hong, H.-C.; Wang, M.-R.; Tseng, Y.-T.; Liao, P.-C.; Chung, M.-C.; Ma, Y.-J.; Wu, S.-C.; Chuang, Y.-J.*; Wang, H.-D.;* Wang, Y.-M.;* Huang, H.-D.;* Lu, T.-T.;* Liaw, W.-F.* “Development of Dinitrosyl Iron Complexes for the Controlled Delivery and Selective Physiological Activity of Nitric Oxide vs. Nitroxyl” J. Biol. Inorg. Chem. 2018, 23, 775-784. 

  • Tzung-Wen Chiou,* Yen-Ming Tseng, Tsai-Te Lu, Tsu-Chien Weng, Dimosthenes Sokaras, Wei-Chieh Ho, Ting-Shen Kuo, Ling-Yun Jang, Jyh-Fu Lee and Wen-Feng Liaw* "[NiIII(OMe)]-mediated reductive activation of CO2 affording a Ni(k1-OCO) complex" Chem. Sci. 2016, 7, 3640-3644

  • Yu-Ting Tseng, Chien-Hong Chen, Jing-Yu Lin, Bing-Han Li, Yu-Huan Lu, Chia-Her Lin, Hsin-Tsung Chen, Tsu-Chien Weng, Dimosthenes Sokaras, Huang-Yeh Chen, Yun-Liang Soo, and Tsai-Te Lu* "To Transfer or Not to Transfer? Development of Dinitrosyl Iron Complex as Nitroxyl Donor for Nitroxylation of FeIII-Porphyrin Center" Chem. Eur. J. 2015, 21, 17570-17573.

  • Tzung-Wen Chiou,* Tsai-Te Lu,* Ying-Hao Wu, Yi-Ju Yu, Li-Kang Chu, and Wen-Feng Liaw* "Development of a Dinitrosyl Iron Complex Molecular Catalyst into a Hydrogen Evolution Cathode" Angew. Chem. 2015, 54, 14824-14829.

  • Tsai-Te Lu, Tsu-Chien Weng, and Wen-Feng Liaw “X-Ray Emission Spectroscopy: A Spectroscopic Measure for the Determination of NO Oxidation States in Fe-NO Complexes.” Angew. Chem. 2014, 53, 11562-11566. (Highlighted by European Synchrotron Radiation Facility, ESRF)

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