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Lu Research Group

Welcomes You

Bioinorganic Engineering

From Innovative Design & Synthesis toward Novel Biomedical Application

Our team welcomes you to join the interdisciplinary research covering chemistry, material science, biology, and biomedical engineering.​

RECRUIT: Welcome to join our lab

We are looking for international MS and PhD students who are enthusiastic, honest, and  passionate about research.

Research Interests

Bioinorganic Engineering

Utilization of metal ions as structural and functional motif assembles metalloenzymes and metalloproteins for a variety of essential processes in biological system. Through artificial evolution, bioinorganic engineering defines the translational incorporation of the inherited nature of synthetic metallocofactors, including (catalytic) reactivity, redox activity, photophysical properties (X-ray, UV-vis, NIR, etc.), and magnetic properties, into organic and inorganic polymers for functional applications. In this bioinorganic engineering lab, we aim to control the generation, capture, stabilization, delivery, transformation, and detection of bioactive gaseous molecules, such as nitric oxide, dihydrogen, and carbon dioxide. Through the  iterative study on structure  and reactivity of dinitrosyl  iron unit [Fe(NO)2], metal-pyrazolate framework, and MOF-derived metal nanoparticle@carbon materials, controlled manipulation of bioactive gaseous molecules will be translated to cancer treatment and regenerative medicine.

Home: Projects
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Spatial, Dosage, and Temporal Control on the Delivery of Nitric Oxide  for Regenerative and Cancer Therapy

Nitric oxide features ubiquitous physiology in respiration, (cardio)vascular, myocardial, immune, and neuronal system. Difficulty in the controlled delivery of nitric oxide, however, retards the translational application in pharmacology and biomedical engineering. In our lab, we utilized the dinitrosyl iron complexes (DNICs) as a novel prodrug for the delivery of nitric oxide and for the NO-related biomedical application. Relying on our development of the synthetic strategy for DNICs, a chemical library of DNICs was established.In terms of controlled release of nitric oxide, we discovered the controlled release of nitric oxide from DNICs triggered by pH, O2, temperature, photolysis, and magnetic field. On the other hand, we successfully applied DNICs for the NO-related anti-aging effect in C. elegans; vasodilation, myocardial relaxation, and myocardial inotropy effect in zebrafish; and reduction of blood pressure, enhancement of angiogenesis, osteogenesis, neurogenesis, tumor vessel normalization, anti-cancer effect, and anti-inflammatory effect in mouse. Regarding the development of DNICs for the delivery of nitric oxide in vivo, we welcome you to continue the investigation of DNICs for NO-related biomedical application through the conjugation with alternative biomedical materials and devices.

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Controlled Generation and Detection of Dihydrogen

Besides its utilization as a renewable and clean energy source, dihydrogen features unexplored potential in inflammatory disease relying on its antioxidant reactivity, in particular, toward hydroxyl radical. However, limited solubility of H2 in aqueous solution and lack of a delivery system hamper the therapeutic efficiency and retard its biomedical application. In our lab, we discovered DNICs as a precursor for preparation of the Fe@FeOx electrode featuring electrocatalytic HER reactivity. To control the location of delivered dihydrogen, development of metal-organic frameworks (MOF) derived metal@porous carbon as implantable materials for catalytic generation of dihydrogen is undergoing. Moreover, MOF-derived metal nanoparticles shielded by porous carbon provide a mechanism for the steady, instead of burst, generation of dihydrogen.

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Direct Air Capture and Controlled Transformation of Carbon Dioxide

魯才德 Tsai-Te (Shawn) Lu

Institute of Biomedical Engineering & Department of Chemistry, National Tsing Hua University
國立清華大學生物醫學工程所;國立清華大學化學系
Phone: 03-5715131#35501⚫ E-Mail: ttlu@mx.nthu.edu.tw

EDUCATION

  • B.S. in Chemistry, National Tsing Hua University, 2005.

  • Ph. D. in Chemistry (Prof. Wen-Feng Liaw, specialized in bioinorganic chemistry), National Tsing Hua University, 2009.

RESEARCH EXPERIENCE

  • Associate Professor

          Institute of Biomedical Engineering, National Tsing Hua University            08/2020- present

  • Assistant Professor

          Institute of Biomedical Engineering, National Tsing Hua University            08/2017- 07/2020

  • Assistant Professor

          Chung Yuan Christian University           08/2013-07/2017

  • Post-doc Research Fellow, Massachusetts Institute of Technology

​          Advisor: Prof. Stephen J. Lippard            3/2011 – 7/2013​

  • Post-doc Research AssociateNational Tsing Hua University

          Advisor: Prof. Wen-Feng Liaw                  12/2009-02/2011

  • Graduate Research AssistantNational Tsing Hua University

          Advisor: Prof. Wen-Feng Liaw                   08/2005-12/2009

AWARDS AND HONORS

  • Young Investigator Award, Shui-Mu Foundation of Chemistry (2023)

  • Excellent Junior Research Investigators, MOST, Taiwan (2020)

  • Young Investigator Award, College of Engineering, NTHU, Taiwan (2020)

  • 科技部GASE中心規委校亮點實驗室, MOST, Taiwan (2020)

  • Young Investigator Award, Chao-Jen Lee (李昭仁) Biomaterial Research Foundation (2019)

  • Outstanding Young Investigator Award, Annual Meeting of Biomaterials and Controlled Release Society in Taiwan (2019)

  • Graeme-Hanson-AsBIC Early Career Researcher Award, Society of Biological Inorganic Chemistry (2018)

  • Rising Star Award, 43rd International Conference on Coordination Chemistry (2018)

  • Visiting Scholar, Dept. of Chemistry Chonbuk National University, South Korea (2018)

  • Excellent Teaching Award, Dept. of Chemistry, Chung Yuan Christian University (2016)

  • Excellent Mentor Award, Dept. of Chemistry, Chung Yuan Christian University (2016)

  • Recruitment of Special Outstanding Talents, MOST (2013)

  • Postdoctoral Research Abroad Program Fellowship, National Science Council (2011)

  • The Phi Tau Phi Scholastic Honor, The Phi Tau Phi Scholastic Honor Society of the Republic of China (2010)

  • NTHU President’s Scholarship, National Tsing Hua University (2006)

PATENTS

  • Tsai-Te Lu, Ting-Yu Chin, Cheng-Ru Wu. “ORAL PHARMACEUTICAL COMPOSITION AND METHOD FOR DELIVERING NITRIC OXIDE TO A PATIENT’S CIRCULATORY” US Patent Under application.

  • 魯才德、金亭佑、吳承儒。”用於口服之醫藥組成物以及醫藥組成物用於製備將一氧化氮傳遞至患者的循環系統或大腦之口服藥劑之用途” 中華民國專利申請中

  • Tsai-Te Lu, Chieh-Cheng Huang, Han Chiu, Wei-Ping Wang, Rui-Ting Wang, Yi-Chieh Lai. “EXTERNAL DERMAL AGENT AND USE OF DINITROSYL IRON COMPLEX FOR PREPARING EXTERNAL DERMAL AGENT” Under application.

  • 魯才德、黃玠誠、邱涵、王蔚平、王瑞婷、賴怡倩。”皮膚外用組成物以及雙亞硝基鐵錯合物用於製備美化皮膚的皮膚外用組成物之用途” 中華民國專利申請中

  • Tsai-Te Lu, Yu-Ting Tseng, Tzu-Chieh Yu, Wen-Feng Liaw. “PYRAZOLE METAL COMPLEX FOR ABSORBING CARBON DIOXIDE, METHOD FOR PREPARING PYRAZOLE METAL COMPLEX, AND METHOD FOR ABSORPTION OF CARBON DIOXIDE” US Patent Under application.

  • 魯才德、曾宇霆、游子頡、廖文峰。”用於吸附二氧化碳之吡唑金屬化合物、其製備方法、及吸附二氧化碳之方法” 中華民國專利申請中

  • Yun-Ching Chen, Tsai-Te Lu, Yun-Chieh Sung “NANOPARTICLE, PREPARATION PROCESS AND USES THEREOF” US Patent App. 16/909,134.

  • 陳韻晶、魯才德、宋雲傑。“奈米粒子及其製備方法與用途”

  • Tsai-Te Lu, Hsiao-Wen Huang, Chia-Her Lin, Yu-Ting Tseng, Wen-Feng Liaw, Hsi-Ya Huang, Show-Jen Chiou “DINITROSYL IRON COMPLEX, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, COMPOSITE MATERIAL COMPRISING THE SAME, AND USES THEREOF” US 10,538,545 B2.

  • 魯才德、黃小紋、林嘉和、曾宇霆、廖文峯、黃悉雅、邱秀貞。” 雙亞硝基鐵錯合物、包含該錯合物之藥學組合物或複合材料及其用途” 中華民國專利 I666214

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Publication List

  1. Tarik Abdelkareem Mostafa Amer, Sathyadevi Palanisamy, Pamela Berilyn So, Priya Vijayaraghavan, Shey-Cherng Tzou, Tsai-Te Lu,* Chia-Her Lin,* Yun-Ming Wang* “Sustained Releasable Copper and Zinc Biogenic ions Co-Assembled in Metal-Organic Frameworks Reinforced Bacterial Eradication and Wound Mitigation in Diabetic Mice” Bioconjugate Chemistry 2023, Accepted.

  2. Yi-Chieh Chan, Ya-Hui Lin, Hsiu-Ching Liu, Ru-Siou Hsu, Min-Ren Chiang,  Li-Wen Wang, Tsu-Chin Chou, Tsai-Te Lu, I-Chi Lee, Li-An Chu,* Shang-Hsiu Hu* “In situ magnetoelectric generation of nitric oxide and electric stimulus for nerve therapy by wireless chargeable molybdenum carbide octahedrons” Nano Today 2023, 51, 101935. 

  3. Wen-Han Chuang, Yu-Ting Chou, Yi-Hong Chen, Ting-Han Kuo, Wen-Feng Liaw, Tsai-Te Lu,* Chih-Fei Kao,* Yun-Ming Wang* “Neuroprotective Effect of NO-delivery Dinitrosyl Iron Complexes (DNICs) on Amyloid Pathology in Alzheimer’s Disease Cell Model” ACS Chemical Neuroscience 2023, Accepted.

  4. Shih-Hao Chang, Hui-Yi Hsiao,* Yi-Hong Chen, Ming-Huei Cheng, Jia-Wei Liu, Hsiao-Jo Huang, Yu-Ting Chou, Tarik Abdelkareem Mostafa Amer, Priya Vijayaraghavan, Sathyadevi Palanisamy, Yun-Ming Wang,* Tsai-Te Lu* “Conjugation of Bone Graft with NO-delivery Dinitrosyl Iron Complexes Promotes Synergistic Osteogenesis and Angiogenesis in Rat Calvaria Bone Defects” J. Mater. Chem. B 2023, Accepted. 

  5. Tsung-Ying Lee, Hung-Hsun Lu, Hui-Teng Cheng, Hsi-Chien Huang, Yun-Jen Tsai, I-Hsiang Chang, Chao-Peng Tu, Chieh-Wei Chung, Tsai-Te Lu,* Chi-How Peng,* Yunching Chen* “Delivery of nitric oxide with a pH-responsive nanocarrier for the treatment of renal fibrosis” J. Control. Release 2023, 354, 417-428. 

  6. Yu-Ting Tseng, Vladimir Pelmenschikov,* Linda Iffland-Mühlhaus, Donato Calabrese, Yu-Che Chang, Konstantin Laun, Chih-Wen Pao, Ilya Sergueev, Yoshitaka Yoda, Wen-Feng Liaw, Chien-Hong Chen,* I-Jui Hsu,* Ulf-Peter Apfel,* Giorgio Caserta,* Lars Lauterbach,* and Tsai-Te Lu* “Substrate-Gated Transformation of a Pre-Catalyst into an Iron-Hydride Intermediate [(NO)2(CO)Fe(μ-H)Fe(CO)(NO)2]– for Catalytic Dehydrogenation of Dimethylamine Borane” Inorg. Chem. 2023, 62, 769-781.

  7. Cheng-Han Chen, Yu-Hsiang Liao, Michael Muljadi, Tsai-Te Lu, Chao-Min Cheng* “Potential Application of the WST-8-mPMS Assay for Rapid Viable Microorganism Detection” Pathogens 2023, 12, 343.

  8. Ibrahim Habib, Tsai-Te Lu,* Amr Sabbah, Kuei-Hsien Chen, Fu-Te Tsai, Wen-Feng Liaw* “One-Pot Photosynthesis of Cubic Fe@Fe3O4 Core−Shell Nanoparticle Well-Dispersed in N‑Doping Carbonaceous Polymer Using a Molecular Dinitrosyl Iron Precursor” Inorg. Chem. 2022, 61, 20719-20724. 

  9. Hsin-Tzu Hsieh, Hsi-Chien Huang, Chieh-Wei Chung, Cheng-Chin Chiang, Tiffaney Hsia, Hsin-Fang Wu, Rui-Lin Huang, Chi-Shiun Chiang, Jane Wang, Tsai-Te Lu,* Yunching Chen* “CXCR4-targeted nitric oxide nanoparticles deliver PD-L1 siRNA for immunotherapy against glioblastoma” J. Control. Release 2022, 352, 920-930. 

  10. Hsi-Chien Huang, Yun-Chieh Sung, Chung-Pin Li, Dehui Wan, Po-Han Chao, Bo-Wen Liao, Hui-Teng Cheng, Fu-Fei Hsu, Chieh-Cheng Huang, Yu-Hui Liao, Hsin Tzu Hsieh, Yu-Chuan Shih, I-Ju Liu, Han-Chung Wu, Tsai-Te Lu*, Jane Wang*, Yunching Chen* “Reversal of Pancreatic Desmoplasia by a Tumor Stroma-targeted Nitric Oxide Nanogel Overcomes TRAIL Resistance in Pancreatic Tumors” Gut 2022, 71, 1843-1855.

  11. Chia-Yi Lee, Tsai-Te Lu, Yaa-Jyuhn James Meir, Kuan-Jen Chen, Chun-Fu Liu, Chao-Min Cheng, Hung-Chi Chen* “Refractive Changes Following Premature Posterior Capsulotomy Using Neodymium:Yttrium–Aluminum–Garnet Laser” J. Pers. Med. 2022, 12, 272. 

  12. Chieh-Wei Chung, Bo-Wen Liao, Shu-Wei Huang, Show-Jen Chiou, Cheng-Han Chang, Sheng-Ju Lin, Bo-Hao Chen, Wei-Ling Liu, Shang-Hsiu Hu, Yu-Chun Chuang, Chia-Her Lin, I-Jui Hsu, Chao-Min Cheng, Chieh-Cheng Huang, Tsai-Te Lu* “Magnetic-Responsive Release of Nitric Oxide from a MOF-derived Fe3O4@PLGA Microsphere for the Treatment of Bacteria-Infected Cutaneous Wound” ACS Appl. Mater. Inter. 2022, 14, 6343-6357. 

  13. Yong-Huei Hong, Manmath Narwane, Lawrence Yu-Min Liu, Yi-Da Huang, Yu-Hsiang Chang, Cheng-Ru Wu, Hsi-Chien Huang, I-Jui Hsu, Ling-Yun Cheng, Liang-Yi Wu, Yu-Lun Chueh, Yunching Chen, Chia-Her Lin, Tsai-Te Lu* “Enhanced Oral NO Delivery through Bioinorganic Engineering of Acid-sensitive Prodrug into a Transformer-like DNIC@MOF Microrod” ACS Appl. Mater. Inter. 2022, 14, 3849-3863. 

  14. Yi-Jen Hsueh, Yaa-Jyuhn James Meir, Jui-Yang Lai, Chieh-Cheng Huang, Tsai-Te Lu, David Hui-Kang Ma, Chao-Min Cheng, Wei-Chi Wu, Hung-Chi Chen* “Ascorbic acid ameliorates corneal endothelial dysfunction and enhances cell proliferation via the noncanonical GLUT1-ERK axis” Biomed. Pharmacother. 2021, 144, 112306. 

  15. Cheng-Ru Wu, Yi-Da Huang, Yong-Huei Hong, Ya-Hsin Liu, Manmath Narwane, Yu-Hsiang Chang, Trinh Kieu Dinh, Hsin-Tzu Hsieh, Yi-Jen Hseuh, Ping-Ching Wu, Chih-Wen Pao, Ting-Shan Chan, I-Jui Hsu, Yunching Chen, Hung-Chi Chen,* Ting-Yu Chin,* Tsai-Te Lu* “Endogenous Conjugation of Biomimetic Dinitrosyl Iron Complex with Protein Vehicles for Oral Delivery of Nitric Oxide to Brain and Activation of Hippocampal Neurogenesis” JACS Au 2021, 1, 998-1013. 

  16. Min-Hsuan Fang, Shiuan-Yau Wu, Yu-Hsiang Chang, Manmath Narwane, Bo-Hao Chen, Wei-Ling Liu, Darwin Kurniawan, Wei-Hung Chiang, Chia-Her Lin, Yu-Chun Chuang, I-Jui Hsu, Hsin-Tsung Chen*, Tsai-Te Lu* “Mechanistic Insight into the Synergetic Interaction of Ammonia Borane and Water on ZIF-67-Derived Co@Porous Carbon for Controlled Generation of Dihydrogen” ACS Appl. Mater. Inter. 2021, 13, 47465-47477. 

  17. Yu-Chieh Chen, Yi-Hong Chen, Han Chiu, Yi-Hsuan Ko, Ruei-Ting Wang, Wei-Ping Wang, Yung-Jen Chuang, Chieh-Cheng Huang,* Tsai-Te Lu* “Cell-Penetrating Delivery of Nitric Oxide by Biocompatible Dinitrosyl Iron Complex and Its Dermato-Physiological Implications” Int. J. Mol. Sci. 2021, 22, 10101. 

  18. Chi-Yen Tung, Yu-Ting Tseng, Tsai-Te Lu*, Wen-Feng Liaw* “Insight into the Electronic Structure of Biomimetic Dinitrosyliron Complexes (DNICs): Toward the Syntheses of Amido-Bridging Dinuclear DNICs” Inorg. Chem. 2021, 60, 15846-15873. 

  19. Chih-Chieh Yu, Ferng-Chang Chang, Yong-Huei Hong, Jian-Chiuan Li, Po-Lin Chen, Chun-Hong Chen, Tzai-Wen Chiu, Tsai-Te Lu, Yun-Ming Wang, Chih-Fei Kao* “Assessing the cognitive status of Drosophila by the value-based feeding decision” NPJ Aging Mech. Disease 2021, 7, https://doi.org/10.1038/s41514-021-00075-6.

  20. Joshua Santos, Mark Tristan Quimque, Rhenz Alfred Liman, Jay Carl Agbay, Allan Patrick G. Macabeo, Mary Jho-Anne Corpuz, Yun-Ming Wang, Tsai-Te Lu, Chia-Her Lin, Oliver B. Villaflores* “Computational and Experimental Assessments of Magnolol as a Neuroprotective Agent and Utilization of UiO-66(Zr) as Its Drug Delivery System” ACS Omega. 2021, 6, 24382-24396. 

  21. Yu-Ting Tseng, Wei-Min Ching, Wen-Feng Liaw,* Tsai-Te Lu* “Dinitrosyl Iron Complex [K-18-crown-6-ether][(NO)2Fe(MePyrCO2)]: Intermediate for Capture and Reduction of Carbon Dioxide.” Angew. Chem. 2020, 59, 11819-11823. 

  22. Shan Lu, Tzung-Wen Chiou,* Wei-Liang Li, Chun-Chieh Wang, Yun-Ming Wang, Way-Zen Lee, Tsai-Te Lu*, Wen-Feng Liaw* “Dinitrosyl Iron Complex [(PMDTA)Fe(NO)2]: Intermediate for Nitric Oxide Monooxygenation Activity in Non-Heme Iron Complex” Inorg. Chem. 2020, 59, 8308-8319.

  23. Chih-Chun Chang, Trinh Kieu Dinh, Yi-An Lee, Fu-Nien Wang, Yun-Chieh Sung, Pei-Lun Yu, Shao-Chieh Chiu, Yu-Chuan Shih, Cheng-Yun Wu, Yi-Da Huang, Jane Wang, Tsai-Te Lu, Dehui Wan, and Yunching Chen* “Nanoparticle Delivery of MnO2 and Anti-angiogenic Therapy to Overcome Hypoxia-Driven Tumor Escape and Suppress Hepatocellular Carcinoma” ACS Appl. Mater. Inter. 2020, 12, 44407-44419. 

  24. Joshua H. Santos, Mark Tristan J. Quimque, Allan Patrick G. Macabeo, Mary Jho-Anne T. Corpuz, Yun-Ming Wang, Tsai-Te Lu, Chia-Her Lin, Oliver B. Villaflores* “Enhanced Oral Bioavailability of the Pharmacologically Active Lignin Magnolol via Zr-Based Metal Organic Framework Impregnation.” Pharmaceutics 2020, 12, 437. 

  25. Yi-Jen Hsueh, Yaa-Jyuhn James Meir, Lung-Kun Yeh, Tze-Kai Wang, Chieh-Cheng Huang, Tsai-Te Lu, Chao-Min Cheng, Wei-Chi Wu, Hung-Chi Chen* “Topical Ascorbic Acid Ameliorates Oxidative Stress-Induced Corneal Endothelial Damage via Suppression of Apoptosis and Autophagic Flux Blockage.” Cells 2020, 9, 943. 

  26. Yi-Jen Hsueh, Yaa-Jyuhn James Meir, Jui-Yang Lai, Hung-Chi Chen*, David Hui-Kang Ma, Chieh-Cheng Huang, Tsai-Te Lu, Chao-Min Cheng, Wei-Chi Wu “Lysophosphatidic acid improves corneal endothelial density in tissue culture by stimulating stromal secretion of interleukin-1β” J. Cell Mol. Med. 2020, 24, 6596-6608. 

  27. Fang-Chi Hsiao, Hung-Ta Chen, Kuan-Jen Chen, Yi-Jen Hsueh, Yaa-Jyuhn James Meir, Tsai-Te Lu, Chao-Min Cheng, Wei-Chi Wu, Hung-Chi Chen* “Accelerated corneal endothelial cell loss in two patients with granulomatosis with polyangiitis following phacoemulsification” BMC Ophthalmology 2020, 20, 480. 

  28. Yun-Chieh Sung, Pei-Ru Jin, Li-An Chu, Fu-Fei Hsu, Mei-Ren Wang, Chih-Chun Chang, Show-Jen Chiou, Jiantai Timothy Qiu, Dong-Yu Gao, Chu-Chi Lin, Yu-Sing Chen, Yi-Chiung Hsu, Jane Wang, Fu-Nien Wang, Pei-Lun Yu, Ann-Shyn Chiang, Anthony Yan-Tang Wu, John Jun-Sheng Ko, Charles Pin-Kuang Lai, Tsai-Te Lu*, Yunching Chen* “Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies” Nat. Nanotechnol. 2019, 14, 1160-1169.  

  29. Yu-Jen Chen, Shou-Cheng Wu, Hsiang-Ching Wang, Tung-Ho Wu, Shyng-Shiou F. Yuan,* Tsai-Te Lu*, Wen-Feng Liaw,* Yun-Ming Wang* “Activation of Angiogenesis and Wound Healing in Diabetic Mice Using NO-Delivery Dinitrosyl Iron Complexes” Mol. Pharmaceutics 2019, 16, 4241-4251. 

  30. Hui-Yi Hsiao, Chieh-Wei Chung, Joshua H. Santos, Oliver B. Villaflores, Tsai-Te Lu* “Fe in Biosynthesis, Translocation, and Signal Transduction of NO: Toward Bioinorganic Engineering of Dinitrosyl Iron Complexes into NO-delivery Scaffolds for Tissue Engineering” Dalton Trans. 2019, 48, 9431-9453. 

  31. Huang-Chia Huang, Wei-Min Ching, Yu-Ting Tseng, Chien-Hong Chen*, Tsai-Te Lu* “Transformation of Hydride-Containing Dinitrosyl Iron Complex [(NO)2Fe(η2-BH4)]– into [(NO)2Fe(η3-HCS2)]– via Reaction with CS2” Dalton Trans. 2019, 48, 5897-5902. 

  32. Szu-Liang Cho, Cheng-Jhe Liao, Tsai-Te Lu* “Synthetic methodology for preparation of dinitrosyl iron complexes” J. Biol. Inorg. Chem. 2019, 24, 495-515.

  33. Tsai-Te Lu*, Yun-Ming Wang,* Chen-Hsiung Hung,* Show-Jen Chiou,* Wen-Feng Liaw* “Bioinorganic Chemistry of the Natural [Fe(NO)2] Motif: Evolution of a Functional Model for NO-Related Biomedical Application and Revolutionary Development of a Translational Model” Inorg. Chem. 2018, 57, 12425-12443. 

  34. Hsiao‑Wen Huang, Yen‑Hung Lin, Min‑Hsuan Lin, Ya‑Rong Huang, Chih‑Hung Chou, Hsiao‑Chin Hong, Mei‑Ren Wang, Yu‑Ting Tseng, Po‑Chun Liao, Min‑Chuan Chung, Yu‑Jie Ma, Shou‑Cheng Wu, Yung‑Jen Chuang,* Horng‑Dar Wang,* Yun‑Ming Wang,* Hsien‑Da Huang,* Tsai‑Te Lu*, Wen‑Feng Liaw* “Extension of C. elegans lifespan using the ·NO‑delivery dinitrosyl iron complexes” J. Biol. Inorg. Chem. 2018, 23, 775-784. 

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